Quantitative assessment of global and regional strain in relation to infarct size in patients with myocardial infarction

Methods Eighty patients with history of past MI were grouped by MI coronary territory {left anterior descending (LAD), left circumflex (LCX), right coronary (RCA)}. Scar quantification was done by computer-assisted planimetry (Medis Qmass v7.2) of gadolinium enhanced delayed images and MI percentage was determined. Global and regional circumferential subendocardial (Ecc Endo) and subepicardial (Ecc Epi) and longitudinal (Ell) strains were derived from three long axis (4, 3 and 2 chamber) and three short axis (basal, mid, apical) steady state free procession cine planes. Semi-automated tracing of endocardial and epicardial borders using FT-MRI (Diogenes MRI, Tomtec Systems) was performed and strains were mapped to a 17 segment AHA model. Repeated measures ANOVA was used to compare normal strain values from 60 healthy subjects to MI patients controlling for scar percentage.